Category: Research & Analysis

New Data Finds 30-day Abstinence Rates Increase Over Time for New JUUL Users

A peer-reviewed study published last week in Harm Reduction Journal found that, after six months of JUUL product use, the proportion of smokers reporting 30-day abstinence from cigarette smoking had climbed from 47% at the three-months follow-up assessment to 54% at the six-months follow-up assessment among the respondent sample (i.e. the participants who provided valid data on cigarette smoking at the follow-up assessments).

A previous peer-reviewed study published in March reported that after three months, nearly half of the participants who smoked combustible cigarettes at the start of the study and completed the three-months follow-up assessment had successfully abstained from cigarette smoking for the prior 30 days after purchasing a JUUL starter kit.

Enrolled sample: the pool of all participants that enrolled in the study at its starting point. The lower percentage numbers represent researchers’ conservative assumption that participants who dropped out of the study or did not respond to the question at one or both of the assessment points, “In the past 30 days, have you smoked a cigarette, even one or two puffs?”, were not abstinent.

Respondent sample: the pool of participants in the study who provided valid data on cigarette smoking at the three-month and six-month follow-up assessment points.

As we continue to work to provide adult smokers an alternative to cigarettes, JUUL Labs is committed to conducting and supporting durably-designed preclinical, clinical, and behavioral research examining the potential public health impact of our products. Our behavioral research program has enrolled over 70,000 participants around the world to date, with the aim of evaluating how adult smokers interact with JUUL products and which attributes impact the odds of transitioning from cigarettes to a nicotine alternative.

This research program is the backbone of what we do at JUUL Labs. We understand that it takes time to observe the real-world impact of our products, which is why we’ve set up multiple extensive, ongoing longitudinal studies that ask tens of thousands of eligible adult participants about their use of JUUL products and combustible cigarettes. We intend to conduct future follow-up assessments in this study for up to 18 months. 

Observing how participants change their behaviors over time gives us valuable insight into the role our product plays in moving adult smokers away from combustible cigarettes. With this information, we can learn what factors drive higher abstinence rates and minimize cigarette consumption among adult smokers.

This 7% increase in prior 30-day cigarette abstinence rate — between the subset of participants who completed the follow-up assessments at the three and six-month mark — is unprecedented and incredibly promising. Evaluating the potential impact of a product like JUUL on adult smokers will take time and patience, much like an adult smoker’s transition from cigarettes to an alternative. The results from this study show us that prolonged access to and use of JUUL products over time could result in a higher likelihood of refraining from smoking cigarettes.

The study found that participants who primarily used non-tobacco flavors were more likely to have not smoked a cigarette in the 30 days prior to the six-months follow-up assessment. For example, compared to those who primarily used tobacco-flavors, odds of reporting prior 30-day cigarette abstinence were 46% and 40% greater among primary users of Mint and Mango flavors, respectively.

We’re incredibly encouraged by these collective findings and the potential public health impact they present. Imagine the impact these numbers represent in the context of the world’s one billion adult smokers. Imagine if over half of those adult smokers moved away from combustible cigarettes to a nicotine alternative. That’s what we’re working towards at JUUL Labs.

Our Commitment to Scientific Research

We look forward to growing our current body of scientific evidence with more preclinical, clinical, and behavioral research. Longitudinal studies like this give us valuable insight into how adult smokers are using our products in the real world, and the results we’ve seen so far may reflect the potential that our product can help adult smokers move away from combustible cigarettes over time.

We will continue to ask the right and relevant questions and present our findings with transparency.

Pilot Study of RACS Program Shows Dramatic Improvement in Retailer Compliance

In August of this year, we implemented a series of new measures in the United States designed to build upon our efforts to combat youth access, appeal, and use of JUUL products and across the category. As part of that announcement, we launched JUUL Labs’ Retail Access Control Standards (RACS) program, a standards-based program tied to a retailer’s point-of-sale system which automatically locks when a JUUL product is scanned and remains locked until a retailer electronically scans a valid, of-age government-issued I.D. to verify both the age and I.D. validity. A RACS-compliant system also limits the amount of product that can be purchased in a single transaction, a policy designed to cut down on social sourcing and illegal third-party sales to underage users. JUUL Labs is the only vapor product company in the U.S. to require its retailers to maintain a mandatory bulk purchase policy which limits each transaction to one device and four refill kits.

Today, the company presented a poster at the 7th Annual Vermont Center on Behavior & Health Conference summarizing the results of a RACS pilot study conducted across a subset of regional convenience stores. The pilot study was designed to assess the system’s effectiveness in improving compliance rates and to monitor its implementation in a real-world setting. Participating retail outlets updated their point-of-sale systems to be RACS-compliant and trained store employees to follow RACS requirements for age verification and bulk-purchase limits. A third-party vendor conducted the pilot study.

From May to June 2019, a total of 3,990 compliance checks were conducted at 171 participating stores, 2,219 in the month prior to the implementation of RACS and 1,771 after implementation of RACS. An age-verification failure post-installation was defined as failure of the retailer to check a customer’s I.D., failure of the RACS system to require scanning of the I.D. prior to purchase, or failure of the RACS system to reject fake, expired, or otherwise invalid I.D.s. A bulk purchase failure post-installation was defined as failure of the scanning system to limit bulk purchases, or a retailer knowingly allowing an individual to complete two or more back-to-back transactions designed to evade the bulk purchase limits.

For both age-verification and bulk-purchasing audits, failure rates dropped drastically after implementing RACS.

  • For age-verification compliance, the overall failure rate fell from 36.8% for JUUL purchases before implementing RACS to 0.2% after implementation.
  • For bulk-purchase compliance, the overall failure rate fell from 29.3% for JUUL purchases before implementing RACS to 1.0% after implementation. 
  • 734 of 2,219 compliance checks resulted in an age-verification or bulk-purchase failure before implementation, while only 11 of 1,771 compliance checks resulted in an age-verification or bulk-purchase failure after implementation.
    • The two age-verification failures were attributable to store clerks scanning their own I.D.s on behalf of the customer.
    • Eight of the bulk-purchase failures were attributable to technical issues, including disabling of the feature, and the remaining failure was attributable to a store clerk allowing back-to-back transactions.

As previously announced, JUUL Labs’ leadership team, under the direction of newly-appointed CEO K.C. Crosthwaite, is overseeing a broad review of the company’s practices and policies to ensure alignment with its aim of responsible leadership within the industry. The preliminary evidence from this pilot study is compelling and demonstrates RACS can be an important component of a larger comprehensive youth-prevention framework that also incorporates marketing restrictions and additional controls.

JUUL LABS PRESENTS NEW DATA ON SECONDHAND VAPOR, ROLE OF FLAVORED PRODUCTS IN SWITCH RATES AND PUFF TOPOGRAPHY AT THE 6TH GLOBAL FORUM ON NICOTINE

This week, we presented new data from three studies that shed light on important environmental, behavioral and product-use factors associated with the use of vapor products, including JUUL. The results were presented at the 6th Global Forum on Nicotine in Warsaw, Poland.

Cigarette smoking remains the number one cause of preventable death worldwide, accounting for more than 8 million deaths each year from both direct use and indirect exposure to combustible smoke. It is critical that we find alternative options to combustible cigarettes for the world’s 1.1 billion adult smokers1and those around them, which is why we are pleased to have the opportunity to share our research at this year’s Forum.

ENVIRONMENTAL EXPOSURE ASSOCIATED WITH THE USE OF VAPOR PRODUCTS

Results from a clinical study of 30 adult smokers found an approximately 99% reduction of formaldehyde and carbon monoxide particles in secondhand (exhaled breath) vapor associated with the use of the JUUL system compared to the use of combustible cigarettes. The aggregate measurements of formaldehyde and carbon monoxide particles were not statistically different from the background levels measured without product use.  

In air quality analyses, concentrations of respirable particles were elevated in every environment and product evaluated. However, the average rise in airborne particles was lower with the JUUL system versus the other vapor product and combustible cigarettes. Room air nicotine levels were 89%–95% lower following ad libitum vapor product use (using the product at their discretion) versus cigarettes. The study authors note the presence and variability of background environmental source chemicals as a factor in the analysis.

These findings align with the current scientific understanding of the role alternative nicotine delivery systems can play for adult smokers and the corresponding environmental impact for those around them.

NON-TOBACCO-FLAVORED JUUL PRODUCTS ASSOCIATED WITH HIGHER LIKELIHOOD OF SWITCHING FROM FROM COMBUSTIBLE CIGARETTES

Results from another study demonstrate adult smokers who primarily used non-tobacco-flavored JUUL products were more likely than those who primarily used tobacco-flavored JUUL products to have successfully switched from smoking combustible cigarettes over a 6-month period.

The study followed more than 37,000 US adult smokers who had recently purchased JUUL products at retail or on the company’s e-commerce platform. Participants completed online surveys over 6 months.

Researchers analyzed data from a subset of 21,332 smokers aged 21+ years who had purchased a JUUL starter kit and completed at least two follow-up assessments. Study participants completed baseline and 30-day, 60-day, 90-day and 180-day follow-up assessments via online surveys. The assessments asked study participants about JUUL flavor use and switching—defined as no smoking, not a single puff— for the previous 30 days prior to the assessment. JUUL Labs commissioned and funded the study, Centre for Substance Use Research (CSUR) independently designed and administered the survey underlying this data analysis. 

Across 30-, 60- and 90-day assessments, use of menthol-based (i.e., Menthol and Mint) and non-tobacco/menthol-based (NTM) flavored JUUL products, compared with the use of tobacco flavored JUUL products, were positively associated with past 30-day smoking abstinence at the 60-, 90- and 180-day assessments. Adult smokers who primarily used menthol-based and NTM flavors were 14% and 7% more likely, respectively, to have switched than those primarily using tobacco flavors across the 6-month study period. 

There has been an active discussion about the role of flavors in supporting adult smokers who want to switch from combustible cigarettes and, at JUUL Labs, we are committed to driving research to inform these discussions. These results add to a growing body of evidence that suggest that the use of vapor products in non-tobacco flavors may potentially help adult smokers switch from combustible cigarettes compared to tobacco flavors.

ADDITIONAL INSIGHT INTO INHALATION PATTERNS (“PUFF TOPOGRAPHY”) IN ADULT SMOKERS

A third study sought to measure real-life puffing behaviors of 30 adult smokers when using JUUL Virginia Tobacco (5% nicotine) over the course of 15 days. On Day 1 and Day 15 of the study, subjects were asked to use the product as they normally would. Researchers then assessed a number of parameters including puff duration, puff volume, flow rate and time between puffs.

Investigators observed a correlation between initial enjoyment of the product and increases in ongoing use parameters, including puff count, puff volume and puff duration. In contrast, adult smokers who reported lower enjoyment tended to diminish use over time and to take shorter puffs over time.

Understanding how adult smokers interact with JUUL products is important because it helps ensure our other clinical and preclinical test conditions, including mechanized puff machines, are correctly calibrated to mimic real-world use of the product among adult smokers, including puff duration and volume. Puff topography studies also provide valuable insight into how the initial use and enjoyment of the product can influence future switching behavior.

Data were collected at Rose Research Center in Raleigh, North Carolina, using the CReSS Pocket, a version of the widely-used Clinical Research Support System for Laboratories reference system. The Center specializes in tobacco dependence research, including research on adult smokers, addiction, smoking cessation, tobacco harm reduction and the use of other tobacco products.

Ongoing inquiry into puff topography and overall user patterns will be important to further the scientific understanding of the potential impact of vapor products as a viable alternative to combustible cigarettes.

JUUL Labs is committed to both conducting and supporting durably designed, painstakingly executed preclinical, clinical, and behavioral research examining the potential public health impact of our products. We are excited to have been a part of one of the largest international conferences on nicotine research and sciences, and look forward to presenting more data going forward on our mission to eliminate combustible cigarettes among adult smokers.

JUUL Labs Presents New Data on the Role of Flavors in Switching from Combustible Cigarettes

JUUL Labs has presented findings on the switching patterns of adult smokers who use the JUUL system in different flavors at the 2nd Scientific Summit on Tobacco Harm Reduction in Athens, Greece. The data are analyses from an ongoing, large-scale study of new JUUL users.

The study was based on an ongoing survey of adult smokers (n=19,595) who purchased a JUUL starter kit and who had reported smoking combustible cigarettes in the previous 30 days at the beginning of the study. Participants were assessed for their continued smoking habits at 60-, 90- and 180-day follow-up periods using an online survey, and the results of these follow-up assessments were averaged. The study examined whether adult smokers who primarily used JUUL products in non-tobacco flavors differ from those who primarily used tobacco-flavored JUUL products in their future switching behavior.

Researchers concluded that, after accounting for both sociodemographic characteristics and smoking behaviors (i.e., past 30-day frequency and daily intensity of smoking), use of JUUL products in menthol-based flavors (Menthol and Mint) and other non-tobacco flavors (Mango, Cucumber, Fruit, Creme) at 30-day follow-up, compared to use of tobacco flavors, were associated with higher average rates of switching across the three subsequent study follow-up assessments (60, 90, and 180 days). Those who used Mint/Menthol had 23% greater adjusted odds of switching from cigarettes compared to a tobacco flavor. Those who used non-tobacco/menthol-based flavors had 18% greater adjusted odds of switching across the follow-up periods compared to tobacco flavors. The unadjusted odds were 53% for Mint/Menthol and 43% for non-tobacco/menthol-based flavors compared with the use of tobacco flavors.

Among the other findings is that users of tobacco-flavored JUUL products smoked combustible cigarettes more frequently and smoked a greater number of cigarettes per day than study participants who primarily used either Mint/Menthol or non-tobacco/menthol-based flavors. In addition, users of primarily tobacco flavors were, on average, more likely to be older, male, and white as compared to those who used Mint/Menthol and non-tobacco/menthol-based flavors.

American Journal of Health Behavior Publishes Study Measuring Prevalence of Awareness and Use of JUUL and Other Vapor Product Among U.S. Adolescents

JUUL Labs issued a statement regarding a behavioral study published in the American Journal of Health Behavior investigating the prevalence of awareness and use of JUUL products among a representative sample of U.S. adolescents, aged 13–17 years. This study was conducted as part of the company’s expansive scientific program to better understand youth-use patterns and develop effective measures to reverse the reported increase in youth use of vapor products, including JUUL.

The study, a cross-sectional, self-complete online survey conducted between Sept. 21, 2018 and Oct. 3, 2018, included a nationally-representative probability sample of 1,017 U.S. adolescents aged 13-17 years. JUUL Labs commissioned and funded the Centre for Substance Use Research (CSUR) and GfK Global Research (now IPSOS) to independently design, administer, and analyze the results for this study. JUUL Labs did not have access to the raw data or exert control over the study.

CSUR, GfK and JUUL Labs met with FDA to discuss the design, conduct, and implementation of the study, and survey questions were adapted from federally-funded tobacco surveys, including the National Youth Tobacco Survey and Wave 1 of the Population Assessment of Tobacco Control (PATH) survey. The study assessed both awareness and self-reported use of the JUUL device, other vapor products, and combustible cigarettes. Researchers received both parental and participant consent before administering the study, and the study protocol and survey instrument were reviewed and approved by an Institutional Review Board.

It is important to note that the U.S. vapor-based e-cigarette market now includes not only a large number of illegal, unlicensed JUUL-plug-compatible products (cartridges that are not manufactured, licensed or sold by JUUL Labs, but said to be compatible with the JUUL system), but also pod-based systems designed to closely resemble the JUUL system. The study did not capture what percentage of self-reported use of a JUUL product was with a product manufactured by JUUL Labs versus copycat or counterfeit products (both vaporizers and pods) manufactured by unrelated, third-party companies — or simply devices mistakenly believed to be a JUUL product by the respondents. JUUL Labs continues to aggressively go after the manufacturers of these illegal products, which are often marketed in kid-appealing flavors that differ drastically from the company’s limited product offering, through legal action and engagement with regulatory authorities.

Adolescent awareness of JUUL products

Approximately 90.3% of adolescents aged 15-17 years and 88.6% of adolescents aged 13-14 years had ever seen or heard of an e-cigarette before this study.  By comparison, 45.5% of 15-17 year-olds and 29.1% of 13-14 year-olds recognized the JUUL brand or product specifically.

Adolescent use of JUUL products

Researchers also assessed prevalence of use among self-reported JUUL product users, including ever use, current use (defined as use on 1-20 days of the past 30 days) and frequent use (defined as use on 20-30 of the past 30 days).

Approximately 7.6% of those aged 15-17 years and 1.5% of those aged 13-14 years reported ever use of a JUUL product. By comparison, 18.4% of 15-17 year-olds and 8.4% of 13-14 year-olds reported ever use of anye-cigarette.

Approximately 4% of those aged 15-17 years reported current use of a JUUL product, with 0.3% reporting frequent use. 8.7% of this age group reported current use of any e-cigarette and 0.8% reported frequent use. 

Approximately 0.8% of adolescents aged 13-14 years reported current use of JUUL products, with no measurable frequent use among this age group. 1.5% of this age group reported current use of any e-cigarette and, similar to JUUL product use, researchers found no measurable frequent use of e-cigarettes generally.

Use of flavors

Among 15-17 year-olds who indicated current JUUL use, Mango was the most commonly reported ‘flavor used most often’ in the past 30 days, followed by Fruit and Mint, respectively. Overall, 2.2% of adolescents aged 15-17 years had ever used a JUUL product andstarted with Mango flavored JUULpods, and 2.3% of adolescents aged 15-17 years had used Mango flavored JUULpods in the past 30 days.

“Peer-reviewed research helps illuminate key issues regarding underage use of vapor products and is vital to informing the formation of long-term, effective solutions,” said Kevin Burns, CEO at JUUL Labs. “We commissioned this study as a first step to assessing underage use of our products and we believe more research on youth prevalence and perception of all vapor products, including JUUL, is needed. This survey data was collected before implementation of our Action Plan last November, including our decision to stop the sale of non-tobacco and non-menthol-based flavored JUUL products to traditional retail. The study results underscore the importance of category-wide actions to fully address and prevent underage use of vapor products, including JUUL, and we stand in strong support of the FDA’s draft guidance restricting the sale of certain flavored products, including JUULpods, at retail outlets and online. The next youth prevalence study we are sponsoring is currently out in the field, and we look forward to sharing those results with the FDA, scientific community and general public once finalized. We remain committed to eliminating underage use of JUUL products, while preserving access for adult smokers seeking a true alternative to combustible cigarettes.”

About the Study

JUUL Labs commissioned and funded the Centre for Substance Use Research (CSUR) to independently design, administer, and analyze the results for this study. Participants between the ages of 13 and 17 whose parents are panelists of the GfK’s KnowledgePanel were selected through a nationally-representative probability sample. The GfK’s KnowledgePanel is the largest probability-based online research panel in the U.S. designed to be representative of the non-institutionalized U.S. population aged 18 years and older. The survey took roughly 20 minutes to complete and each individual received $25 for their participation. The study protocol and survey instrument was approved by Advarra Institutional Review Board. CSUR will administer an identical survey to a similarly sized probability sample of US adolescents aged 13-17 years in April and May of 2019.

CIGARETTE SALES IN THE U.S. CONTINUE HISTORIC DECLINE INTO THE FIRST QUARTER OF 2019

Cigarettes are the leading cause of preventable death in the U.S. Almost twice as many Americans die from smoking-related illnesses – nearly half a million – than from obesity, alcohol, automobiles, and guns combined. The accelerating decline in cigarette consumption reinforces JUUL Labs’ mission to improve the lives of the world’s one billion adult smokers by eliminating cigarettes.

The latest U.S. syndicated market data tracking cigarette sales are showing sustained declines while JUUL continues to gain share of the combined cigarette pack and JUULpod market. In the past two Nielsen four-week periods, cigarette volumes have faced year-over-year declines of 8 percent or more — numbers not seen in the past 4 years based on available data. These unprecedented declines are a continuation of the disruption the industry has faced since the second half of 2018, where the cigarette market faced consistent volume declines averaging more than 5 percent. The impact of this disruption is significant, as even a 1 percent annual decline in cigarette volumes represents approximately 125 million packs of combustible cigarettes disappearing from the U.S. market.

These changes in the U.S. tobacco market are a testament to the success of JUUL products in switching adult smokers off combustible cigarettes.”

Kevin Burns, JUUL Labs CEO

For the 4-week period ending in late March, year-over-year declines for cigarette pack volumes worsened, falling to 8.8 percent, according to U.S. syndicated market data from Nielsen. This was the second consecutive month featuring year-over-year cigarette pack volume declines of 8 percent or more. JUUL’s share of the combined cigarette market and JUULpod market increased to 6.5 percent in the 4-week period ending March 23.

These historic gains for JUUL within the cigarette market have occurred rapidly, as cigarette volume declines rested at under 2.9 percent in May 2018, while JUUL’s share of the combined cigarette and JUULpod market was only 3.3 percent.

Multiple factors have driven the long-term trend in cigarette declines, but we believe the largest recent contributor, particularly over the past 12 months, has been the growth of JUUL products as a true alternative for smokers.

In total, JUULpod volume increased by 424 million pods over the past 12 months as compared to the previous twelve months, while the decline in cigarette pack volume exceeded 597 million cigarette packs over the same time frame.

In markets where JUUL products have high market penetration, cigarette volume declines are even more pronounced. In JUUL Labs’ top five syndicated markets as measured by Nielsen — NYC, Portland, Oklahoma City and Tulsa, Seattle, Denver – declines accelerated on a trailing 12-week basis from down year-over-year 3.8 percent one year ago to down 9.9 percent year-over-year in the latest period.

More broadly, the data from Nielsen appear to suggest a negative correlation between JUUL products and cigarette pack volumes. In the top 25 U.S. cities measured by Nielsen, as sales of JUUL products increased, combustible cigarette sales plummeted.

In addition to Nielsen, syndicated market data provider IRI is showing nearly identical volume declines for the cigarette market and gains for JUUL. For the 4-week period ending March 24, cigarette pack volumes declined 8.7 percent year-over-year, according to IRI, while JUUL’s share of the combined cigarette market and JUULpod market held steady at 5.7 percent.

These data are an encouraging trend and is why JUUL Labs will continue to tirelessly work to improve the lives of the world’s one billion adult smokers.

PEER-REVIEWED STUDY: HARM REDUCTION JOURNAL PUBLISHES RESULTS FROM BEHAVIORAL STUDY HIGHLIGHTING THE IMPACT OF JUUL USE

The study examined past 30-day smoking abstinence rates three months after initial JUUL product purchase among a sample of 15,456 adult smokers aged 21+ years.  Abstinence was defined as zero puffs of a combustible cigarette in the past 30 days.  Results showed that 47.1 % of the 9,272 survey participants who completed the 3-month follow-up assessment had completely abstained from smoking for the prior 30 days.  Overall, 28.3% of all 15,456 participants who began the study abstained from smoking during the reporting period.

Importantly, the study also found that participants who had exclusively used non-tobacco flavors Mango, Cucumber, Fruit, Creme, Menthol, and Mint were 30% more likely to have abstained from smoking at three months compared to those who exclusively used tobacco flavors.  In addition to being the most commonly used flavors, smokers who primarily used Mint or Mango JUULpods in the 30 days prior to the 3-month assessment were 37% and 26% more likely, respectively, to have not smoked any cigarettes in the previous 30 days compared to primary users of Virginia Tobacco flavored JUULpods.

In total, the study identified eight variables that were significant in predicting the likelihood of past 30-day smoking abstinence after using JUUL products for three months, including frequency of JUUL use, smoking heaviness and duration, place of purchase, and purchase with intent to stop smoking completely.  Future analyses will include data from the same participants at 6 and 12-month follow-up assessments after initiating use of JUUL products.

“The results of this study indicate that close to half of adult smokers who used a JUUL product for three months had abstained from smoking for the past 30 days, with even higher rates of abstinence observed among those who primarily used JUULpods in non-tobacco flavors,” said Dr. Neil McKeganey, Director of the Centre for Substance Use Research (Glasgow, UK).  “Although additional follow-up research is needed, flavored JUULpods have been shown to have a significant impact in getting smokers to switch and ultimately abstain from cigarettes over a period of time.  We will continue to track this and other variables impacting smokers’ likelihood of abstaining from cigarette use, including collecting additional survey data at both the 6 and 12-months mark after initiating JUUL use.”

“Our mission is to improve the lives of the world’s one billion smokers by eliminating cigarettes and we are encouraged by these study findings that approximately half of smokers switch away from combustible cigarettes after three months of JUUL use,” said Erik Augustson, Ph.D., MPH Senior Director of Behavioral Research at JUUL Labs. “We are committed to continuing to research the potential public health impact of our products and have over 100,000 participants enrolled in behavioral studies across the world, where we are collecting data on a range of topics, including factors that improve the likelihood of completely switching from combustible cigarettes and the role responsible flavors may play in that process.”

About the Study:

JUUL Labs commissioned and funded the Centre for Substance Use Research (CSUR) to independently design and administer the survey, and analyze and report the study results. Individuals were invited to participate in this study through email invitations to e-commerce customers and through inserts in JUUL starter kits distributed in retail stores across the U.S.  Eligible individuals were U.S. adults aged 21 years and older who had smoked at least 100 cigarettes in their lifetime, and had purchased their first JUUL starter kit from a U.S. retail store or through JUUL’s e-commerce store at www.juul.com within the past seven days.

Peer-Reviewed Study: Adult Smokers Using JUUL Dramatically Cut Quantity of Cigarettes Smoked

JUUL Labs issued a statement today regarding a new peer-reviewed study published in the Journal of Pulmonary and Respiratory Medicine examining cigarette reductions by adult smokers using JUUL products.

The study tracked the use patterns of 9,272 adult smokers who purchased their first JUUL starter kit from either a retail store or online (JUUL.com); the study enrollment window was within 7 days of purchase. Of these new JUUL users, 7,721 provided detailed information about the frequency and intensity of their smoking in the 30 days prior to purchase of a JUUL starter kit (baseline consumption) and the 30 days prior to a three-month follow-up after initiating on JUUL products (the three-month assessment).

Total cigarette consumption among those participants decreased approximately 73%, from 2,074,664 cigarettes (103,733 packs) per month at baseline to 551,863 cigarettes (27,593 packs) per month at the three-month assessment.

Approximately 47% of participants reported completely switching off of combustible cigarettes at the three-month follow-up assessment.  Switching was defined as not having smoked cigarettes, not even a puff, in the past 30 days.  This group’s total cigarette consumption had fallen from 929,976 cigarettes (46,499 packs) at baseline to zero cigarettes at the three-month assessment. 

The participants who responded that they had smoked a cigarette in the past 30 days were asked three further questions, including:

  • “Do you now smoke cigarettes?” (every day; some days; not at all);
  • “On how many of the past 30 days did you smoke cigarettes?” (1-30 days); and
  • “On those days that you did smoke, how many cigarettes did you usually smoke each day? A pack usually has 20 cigarettes in it.”  

Among the participants still smoking three months after initiating JUUL products, cigarette consumption had declined 51.7% from 1,144,688 cigarettes (57,234 packs) at baseline to 551,863 cigarettes (27,593 packs) at the three-month assessment.

“We are encouraged by the growing body of peer-reviewed research demonstrating the significant impact JUUL products may have on helping adult smokers eliminate or substantially decrease their cigarette consumption,” said Kevin Burns, CEO at JUUL Labs. “Participants in this study dramatically decreased their cigarette consumption after initiating on JUUL products, consuming 73% fewer cigarettes per month, equaling over 76,000 packs.  The study results provide one more important piece of evidence in assessing the potential public health impact of JUUL products.  Our goal is to help all adult smokers completely switch off combustible cigarettes and eliminate their consumption entirely and we look forward to conducting additional research to guide us on achieving that goal.”

About the Study

JUUL Labs commissioned and funded the Centre for Substance Use Research (CSUR) to independently design, administer, and analyze the results for this study. Eligible individuals were U.S. adults aged 21 years and older who had smoked at least 100 cigarettes in their lifetime, who were smoking ‘every day’ or on ‘some days’, when they purchased their first JUUL starter kit from either a retail store or online (JUUL.com) within the past seven days (i.e. a new JUUL user).

Invitations to participate in the study appeared following purchase of starter kit listed on JUUL.com and were also inserted into the packaging of 500,000 JUUL starter kits, which were then randomly distributed to approximately 10,000 licensed store retailers. Of the 9,272 individuals who participated in the study, 7,721 provided detailed information on their smoking habits at both baseline and completed the three-month follow-up assessment.

Findings from Juul Labs’ Behavioral-Science Program Presented at the Society for Research on Nicotine & Tobacco 2019 Annual Meeting

JUUL Labs today announced findings from seven behavioral studies examining youth prevalence and perception of vapor products, including JUUL, and variables impacting adult smokers who successfully switch from combustible cigarettes to JUUL products.  The findings were presented at the 2019 Annual Meeting of the Society for Research on Nicotine and Tobacco (SRNT) in San Francisco.  The posters presented included: 

  • U.S. Adolescents’ Interest in Using E-Cigarettes in Flavors Marketed and Not Marketed by JUUL Labs
  • U.S. Adolescents’ Perceptions of the Harmfulness and Addictiveness of Using a JUUL E-Cigarette Compared to Smoking Conventional Cigarettes
  • Prevalence of Awareness and Use of JUUL E-Cigarettes, E-Cigarettes and Combustible Cigarettes in a National Probability Sample of U.S. Adolescents
  • U.S. Adolescents’ Initiation and Past 30-Day Use of Pod Flavors Marketed and Not Marketed by JUUL Labs
  • Factors Associated with Past 30-Day Abstinence from Cigarette Smoking in a Non-Probabilistic Sample of 15,456 Adult Established Current Smokers in the United States who Used a JUUL Vaporiser for Three Months
  • Identifying Predictive Attributes of Adult Smokers Who Cease Combustible Smoking using the JUUL Electronic Nicotine Delivery System (ENDS) via Logistic Regression and CART
  • Differences among Subgroups of Adult Smokers using JUUL in Switching from Smoking after 90 Days 

Youth Prevalence and Perception, Including Use of Copycat JUUL Products

One survey, conducted between September 21and October 3, 2018, assessed awareness and use of JUUL products, other e-cigarettes, and combustible cigarettes among a probabilistic sample of 1,015 U.S. adolescents aged 13-17 years.  The representative survey found that the majority of participants had never seen or heard of JUUL products, while less than 5% of participants reported using a JUUL product in the past 30 days, and less than 0.3% reported frequent use (defined as use on more than 20 of the past 30 days).

Another survey, conducted between November 23 and December 13, 2018, assessed patterns of use, intentions to use, and perception of JUUL, other e-cigarettes, and combustible cigarettes among a non-probabilistic sample of 9,872 U.S. adolescents aged 13-17 years. To be eligible for the survey, respondents must have heard of or seen JUUL products, in an effort to better understand use and perception patterns of this subset of the population.

Participants who identified themselves as JUUL users were asked the first pod flavor they ever used in a JUUL vaporizer and the pod flavors they had used with a JUUL vaporizer in the past 30 days.  They were provided a list containing the eight flavors manufactured and sold by JUUL Labs (known as “JUULpods”), and 28 flavors not manufactured or sold by JUUL Labs, such as Iced Pina Colada and Watermelon.  The U.S. vapor-based e-cigarette market now includes not only a large number of illegal, unlicensed JUUL-plug-compatible products (cartridges that are not manufactured, licensed by or sold by JUUL Labs, but said to be compatible with the JUUL ENDS vaporizer system), but also pod-based systems designed to look closely like the JUUL system.

Self-reported ever-users of a JUUL vaporizer were more likely to have reported having initiated use of a JUUL vaporizer with a pod flavor not manufactured by JUUL Labs (54.0%) than with a pod flavor manufactured by JUUL Labs (31.2%). Additionally, for current users (use within the past 30 days), they were as likely to have reported having used a pod flavor manufactured by JUUL Labs as a pod flavor marketed by one of these other manufacturers. The survey did not capture what percentage of reported use of a pod flavor manufactured by JUUL Labs was from plug-compatible products offered in JUUL flavors versus products actually manufactured by JUUL Labs.  Survey participants were also significantly more likely to report having initiated use with a pod containing a non-tobacco/menthol/mint flavor (58.7%) than a tobacco flavor (5.6%) or menthol/mint flavor (20.9%).

“These behavioral studies provide valuable insight into youth prevalence and perception of all vapor products, including JUUL products, and further illustrate the importance of category-wide action to restrict access from youth, including clearing the market of illegally marketed products,” said Kevin Burns, Chief Executive Officer at JUUL Labs. “As we have said before, the data demonstrates that we must take decisive action, which is why last November we launched a comprehensive action plan to combat underage use.  Despite the significant actions we have taken to limit the availability of all JUUL products to adults, youth continue to have access to and use a variety of other products, including illegal JUUL-compatible flavored products that are not manufactured or sold by JUUL Labs. We remain committed to leading our category to address youth access and use of vapor products, while simultaneously fulfilling our mission to eliminate cigarettes among adult smokers across the globe.”

About the Studies

Juul Labs, Inc. commissioned and funded the Centre for Substance Use Research (CSUR) to independently design and administer the youth prevalence and perception surveys, and analyze and report the study results.  CSUR developed the study protocol, created the survey instrument, drafted the informed consent forms, and obtained approval from an institutional review board. Parental consent was obtained for all participants.  Juul Labs did not see the raw data or exert control over the study.

Equivalent Reductions in Cigarette-Related Biomarkers Between Smokers Who Switched to JUUL and Those Who Abstained from Cigarettes

JUUL Labs today announced results from a clinical study which found equivalent reductions in select short-term biomarkers of exposure (BOE) between adult smokers who exclusively switched to JUUL products and those who abstained from smoking over a five-day period.  Results from the study, “Changes in Biomarkers of Exposure Associated with Switching for 5 Days from Combusted Cigarettes to Nicotine Salt Pod System,” were presented at the U.S. Society for Research on Nicotine & Tobacco (SRNT) 2019 Annual Meeting in San Francisco, CA. 

The study, a randomized, open‑label, parallel‑group, inpatient study of adult smokers, was sponsored by JUUL Labs and conducted by Celerion, Inc., a third-party research laboratory.  It examined changes, relative to baseline, in primary urine and blood BOEs in 90 adult smokers.  The selected short-term biomarkers, NNN, NNAL, 3-HPMA, MHBMA, S-PMA, HMPMA, CEMA, 1-OHP, and COHb, are carcinogens and toxicants observed in the use of combustible cigarettes, and are widely recognized as contributing to tobacco-related cancers, and heart and lung disease.

Study subjects were randomized into six groups and, over five days, used a nicotine salt pod system (NSPS/JUULpod), abstained from smoking, or continued use of their usual brand of cigarettes. NSPS users were further randomized into four distinct groups (15 subjects per group), and used one of four flavored products at 5% nicotine strength (Virginia Tobacco, Mint, Mango, or Creme). Before the baseline reading, subjects abstained from smoking for 12 hours to assess the BOE impact from NSPS use, abstinence, or cigarette consumption.

The study found that all eight non-nicotine urine BOEs were reduced by an aggregate of 85.3% in the abstinence group compared to an 85.0% aggregate reduction in the pooled NSPS group (p > 0.05).  This represents a 99.6% relative reduction in aggregate BOEs for the pooled NSPS group.  In the cigarette group, the same BOEs increased by an aggregate of 14.4% from baseline.

“We are very pleased to share these findings with fellow researchers at SRNT 2019, which continue to demonstrate the potential positive impact of vapor products,” said Kevin Burns, Chief Executive Officer at JUUL Labs.  “The equivalent reductions in these specific cigarette-related biomarkers across the groups who abstained from smoking and those who used JUUL products reaffirms the role vapor products can have for the adult smoker.  Although addictive, nicotine is not directly responsible for the cancers that are commonly associated with cigarette use; rather it is the harmful constituents that are present in combustible smoke.  The more that can be done to eliminate cigarettes, the greater the impact will be on the public health.  We are committed to conducting rigorous, scientific research as we contribute to the ongoing dialogue regarding vapor products, and look forward to sharing additional research with the medical, scientific, and public health communities.” 

Consistent with FDA regulations, JUUL Labs cannot and does not make any claims that its products are less harmful or safer than cigarettes.

Studies Provide Insights on Role of Flavors to Help Adult Smokers in the U.S. Switch Off Combustible Cigarettes

Two recent survey-based behavioral studies conducted by the Centre for Substance Use Research (CSUR), an independent, U.K.-based research center, of both retail and online customers, indicate that non-tobacco-flavored JUULpods are helping adult smokers in their switching journey from combustible cigarettes. After 90 days of JUUL use, adult smokers who primarily used Mint or Mango demonstrated the highest switch rates from combustible cigarettes, respectively.

As part of our action plan to combat youth usage of our products, we stopped accepting retail orders for non-tobacco/mint/menthol flavored JUULpods on November 13, 2018. We continue selling them only at JUUL.com, which features an industry-leading age verification system that restricts sales of all products to people 21 or older, as well as prevents bulk purchases.

The first study included 7,823 U.S.-based, adult smokers who purchased JUUL Starter Kits in retail outlets. Among the 4,260 respondents who completed the 90-day follow-up assessment, adult smokers who primarily used Mango and Mint demonstrated the highest switch rates. Fifty-eight percent of Mango users and 61 percent of Mint users had fully switched off combustible cigarettes for at least the last 30 days. Comparatively, 40 percent of Menthol users and 34 percent of Classic Tobacco users demonstrated completely switching for at least the last 30 days.

The second study included 7,633 U.S.-based, adult smokers who purchased JUUL Starter Kits through JUUL.com’s e-commerce platform. Of the 5,012 respondents who completed the 90-day follow-up assessment, those who primarily used Mint, again, demonstrated the highest switching rates, with 47 percent responding as having completely switched off combustible cigarettes for at least the last 30 days. Of those who primarily used Mango, 45 percent of respondents reported completely switching off cigarettes for at least the last 30 days. The lowest 90-day switch rate for adult smokers was observed among primary users of Classic Tobacco at 18 percent.

Mint and Mango were not only the options with the highest switching rates, they were also the most popular ones. Across both studies, Mint and Mango represented the highest frequency of primary use flavors among respondents who switched at the 90-day assessment. 

In the retail study, 26 percent of respondents who switched after 90 days primarily used Mango and 24 percent primarily used Mint.Similarly, in the e-commerce study, 27 percent of respondents who switched after 90 days primarily used Mango and 22 percent primarily used Mint. 

Note: Data in the second figure does not add up to 100% because a small number of switchers did not provide data on the flavor pods used.

These real-world, representative studies provide strong evidence that adult smokers not only are using flavored JUUL products, but that these products are also facilitating their switch from combustible cigarettes. Public health experts note that using flavors to dissociate from the taste of tobacco can help ease a smoker’s journey off combustible cigarettes.

“These results add to a growing body of scientific studies confirming what makes common sense,” said Dr. David B. Abrams, a professor of Social and Behavioral Sciences at NYU College of Global Public Health. “Smokers who find a satisfying alternative to cigarettes are more likely to switch if their vape device helps to forget the taste and smell of their cigarettes.”

“Flavors are an essential element of encouraging switching to vaping, and we need regulations that focus on a risk-benefit analysis rather than inadvertently perpetuating the cigarette epidemic,” said David Sweanor of the Center for Health Law, Policy and Ethics at the University of Ottawa.

An in-depth analysis of the data from both studies has been submitted by CSUR to a medical journal for peer review.

About the Studies:

JUUL Labs commissioned CSUR to independently design, administer, and analyze the results for both the e-commerce and retail studies. Study participants were asked to report primary flavor use at each follow-up point. A comparison of switching rates at 90 days of JUUL use, across flavored products, shows variation in switching rates by flavor.

For the retail study, invitations to complete an online survey were inserted into the packaging of JUUL Starter Kits, which were then distributed at random to approximately 10,000 licensed store retailers. The first 7,823 who qualified for the study were enrolled.

For the e-commerce study, invitations to complete an online survey about the use of cigarettes, JUUL products, and other e-cigarettes and vapor products were sent to approximately 37,536 U.S. adults aged 21 years and older who had recently purchased the JUUL Starter Kit from JUUL.com and consented to be contacted by JUUL Labs.

Cigarette Decline Rates Accelerate As JUUL Share Grows

Cigarette pack volumes are declining at an accelerated rate while JUUL Labs’ sales volume, measured as a percentage of United States combustible cigarette market, has grown over the past year. Averaging syndicated data from IRI and Nielsen, industry standard data sets, we see cigarette volumes have experienced a year-over-year decline greater than 5 percent in each of the last 4 months – a trend that has not been seen in the past 5 years of available data. Volume declines for the tobacco industry have worsened over the last two months, with volume decline rates in excess of 7% year-over-year. As cigarette sales continued to tumble in November, JUUL Labs’ share of the combined cigarette market and JUULpod market increased to an average of 6 percent based on data from IRI and Nielsen.

These sustained losses for the industry are unprecedented, as the major cigarette companies saw an annualized average rate of decline of only 1.9 percent from 2014 to 2017.

Multiple factors have driven the long-term trend in cigarette declines, but the largest recent contributor, particularly over the past several months, has been the growth of JUUL products as a true alternative for smokers.

JUUL Labs’ share of the combined cigarette market and JUULpod market has grown from just over 1 percent in January to 6 percent for the month of November using the average IRI and Nielsen data. In total for 2018, the year-over-year increase in JUULpod sales volume is equal to roughly 60 percent of the total cigarette pack declines year-over-year. On average, JUULpod volume reached over 300 million pods, while the decline in cigarette pack volume exceeded 500 million. Common economic factors that have driven sharp declines in cigarettes in the past, such as federal and state tax increases, increased regulation, or outsized gas price increases, are notably absent over this time period.

The impact of this disruption is significant, as even a 1 percent decline in cigarette volumes represents approximately 125 million packs of combustible cigarettes disappearing from the United States market. It has been well established that cigarettes are the leading cause of preventable deaths in the U.S. – almost twice as many Americans die from smoking-related illness than from obesity, alcohol, automobiles, and guns combined. The accelerating decline in cigarette consumption reinforces JUUL Labs’ mission to provide an alternative to the world’s one billion adult smokers.

New Research Continues To Provide Data Regarding The Impact JUUL Products Have On Smokers Trying To Switch From Combustible Cigarettes

Two new survey-based behavioral studies conducted by the Centre for Substance Use Research (CSUR), an independent, UK-based research center, of both online and retail customers, indicate JUUL products are helping adult smokers switch from combustible cigarettes.

The first survey sampled 7,633 adult smokers who purchased JUUL Starter Kits through JUUL.com, the Company’s ecommerce platform. 40.3 percent of the 5,012 participants who responded to a 90-day follow-up had reported completely switching from combustible cigarettes for at least the last 30 days. Total cigarette consumption among those participants decreased 56 percent, from roughly 1.37 million cigarettes in the 30 days prior to the study, to roughly 600,000 cigarettes in the 30 days prior to the 3-month assessment.

The second survey sampled 7,823 adult smokers who purchased JUUL Starter Kits in retail outlets. 56.4 percent of the 4,260 participants who responded to a 90-day follow-up had reported completely switching from combustible cigarettes for at least the last 30 days. Cigarette intake from 3,833 participants who gave detailed information on smoking habits declined 79 percent, from 970,000 to 210,000 per month. In-depth analyses of the data from both the retail and ecommerce samples have been submitted by CSUR to a medical journal for peer review.

Most of the variation in the switching rates between the two studies was accounted for by differences in the two samples on key demographics, smoking history, and user intent.  After statistical adjustment to align these key demographics, the differences were small. Therefore, a closer look at comparable demographics shows aligning rates.

For example, heavy smokers, those smoking 10 or more cigarettes per day, experienced switching rates of more than 30 percent in both surveys. Light smokers, consuming less than 10 cigarettes per day, with no intent to switch, showed switching rates over 50 percent in both the retail and e-commerce survey.

“These results support the notion that JUUL offers a real alternative to adult smokers looking to switch from combustible cigarettes, which remain the number one cause of preventable death worldwide,” said Kevin Burns, Chief Executive Officer of JUUL Labs.  “We are steadfast in our commitment to fund clinical and behavioral research to add to the growing body of scientific evidence regarding vapor technology.”

The e-commerce and retail studies evaluated the frequency of an individuals’ cigarette smoking across a 3-month period to gauge whether or not adults who purchased the JUUL device switched from combustible cigarettes.

The Latest Data:


About the Surveys:

JUUL Labs commissioned CSUR to independently design, administer, and analyze the results for both the e-commerce and retail surveys. The primary outcome measure of the study, switching, was defined as not having smoked cigarettes, not even a puff, in the past 30 days. The secondary outcome measure was the change in the total number of cigarettes smoked by participants in the 30 days prior to each assessment compared to the total number of cigarettes smoked in the 30 days prior to the baseline assessment.

For the e-commerce survey, invitations to complete an online survey about the use of cigarettes, JUUL products, and other e-cigarettes and vapor products were sent to approximately 37,536 U.S. adults aged 21 years and older who had recently purchased the JUUL Starter Kit from the Company’s website and consented to be contacted by JUUL Labs.

For the retail survey, invitations to complete an online survey were inserted into the packaging of JUUL Starter Kits, which were then distributed at random to approximately 10,000 licensed store retailers. The first 7,823 who qualified for the study were enrolled.

JUUL Labs Presents Findings from Cytotoxicity Study at The Tobacco Science Research Conference

SAN FRANCISCO (September 17, 2018) – JUUL Labs, Inc. today announced results from a preliminary study on the cytotoxicity of aerosol generated from JUUL’s Menthol, Mint and Cucumber 5% nicotine-e-liquid filled pods. The findings, “Neutral Red Uptake (NRU) Cytotoxicity Analysis of Aerosol Generated from a Temperature-Regulated Nicotine-Salt Based Ends Product,” were presented at a poster session at the 72nd Tobacco Science Research Conference in Memphis, TN.

In accordance with the Organisation for Economic Co-operation and Development (OECD) guidelines, an independent contract laboratory, Enthalpy Analytical, measured and compared the toxicity to living cells of aerosol generated from JUUL’s Menthol, Mint and Cucumber 5% nicotine-e-liquid filled pods with that of tobacco cigarettes. The study demonstrated no significant aerosol toxicity at any of the observed concentrations for JUUL’s Menthol, Mint and Cucumber pods compared to a cigarette control.

“We are encouraged by the results of this study, in which tested aerosols generated from JUUL were not cytotoxic to living cells,” said Dr. Manoj Misra, study author and head of Toxicology at JUUL Labs. “These findings add to the growing body of evidence regarding use of JUUL as an alternative to combustible cigarettes, and we are committed to future rigorous, independent and peer-reviewed clinical trials and behavioral studies.”

Authors of the study include Dr. Manoj Misra of JUUL Labs and Drs. I. Gene Gillman and Pooja Desai of Enthalpy Analytical.

 

About JUUL Labs

JUUL Labs is a technology company dedicated to eliminating cigarettes by offering existing adult smokers a true alternative to combustible cigarettes. The company’s research shows that more than one million smokers have already switched to JUUL, and we are working to enable millions more to switch in the coming years through technological innovations.

Media Contact: press@juul.com

STATEMENT REGARDING THE FINDINGS FROM THE LARGEST SURVEY TO DATE OF 18,799 U.S. ADULTS WHO HAVE PURCHASED JUUL

From Kevin Burns, JUUL Labs Chief Executive Officer.

SAN FRANCISCO (June 28, 2018) – JUUL Labs issued a statement today from its Chief Executive Officer, Kevin Burns, on findings from the largest survey to date of 18,799 U.S. adults who have purchased JUUL.

Among the results announced by the Center for Substance Use Research (CSUR), an independent UK-based research center, 64.3% of 11,689 adults (aged 21 years or older) who participated in the survey and reported they were smokers when they first used JUUL, also reported they now no longer smoke. Almost 50% (49.5%) reported they completely stopped smoking cigarettes by switching to JUUL. Of the 18,799 survey respondents, 55 (0.3%) reported they were never smokers when they first used a JUUL and are now current smokers. Of the 4,695 participants who had smoked in the past but were not smoking when they first used a JUUL, 7.6% reported they are now current smokers. These relapsed former smokers accounted for 1.9% of all participants.

“Our mission is to eliminate cigarette smoking in the world by providing adult smokers with a true alternative to cigarettes. We are encouraged by these survey results, and we look forward to continuing to engage with the FDA regarding the relevance of switching data to the public health impact of JUUL.

“Tobacco smoking is still the leading preventable cause of death and disease in the U.S. Vapor technology offers the potential to improve the lives of adult smokers. We remain steadfast in our commitment to fund clinical and behavioral research to add to the growing body of scientific evidence regarding vapor technology.”

About the Survey
JUUL Labs commissioned CSUR to independently design, administer and analyze the survey results. Email invitations to complete an online survey about use of cigarettes, JUUL and other e-cigarettes, and vapor products were sent to approximately 89,000 U.S. adults aged 21 years and older who had made at least one online purchase of a JUUL from the Company’s website and consented to be contacted by JUUL. A total of 18,799 adults completed the survey and received a $30 virtual Visa Reward Card. A detailed white paper of the research findings is available: Russell et al 2018 – Smoking Transitions Among JUUL Users.

About JUUL Labs

JUUL Labs is a technology company dedicated to eliminating cigarettes by offering existing adult smokers a true alternative to combustible cigarettes. The company’s research shows that more than one million smokers have already switched to JUUL, and we are working to enable millions more to switch in the coming years through technological innovations.

Media Contact: press@juul.com

JUUL Labs Presents Findings at the Global Forum on Nicotine 2018

SAN FRANCISCO (June 15, 2018) – JUUL Labs today announced preliminary results from a study on harmful and potentially harmful constituents (HPHCs) in JUUL’s nicotine-filled pods. The findings, “HPHC Analysis of Eight Flavors of a Temperature-Regulated Nicotine Salt-Based ENDS Product,” were presented at a poster session at the Global Forum on Nicotine (GFN) 2018 in Warsaw, Poland.

The study, performed by an independent contract laboratory, examined HPHCs in aerosol generated from JUUL’s nicotine-filled pods consisting of eight different flavors. A panel of analytes, including HPHCs identified by the U.S. Food and Drug Administration (FDA), was measured and compared with combustible cigarettes. For all flavors, across 22 panel analytes measured, all analytes were below the level of quantification or detection.

“Clinical research builds the foundation of JUUL, and we remain steadfast in our commitment to share data with the scientific community,” said Gal Cohen, Senior Director of Scientific Affairs at JUUL Labs. “We are pleased to present the findings from one of our studies at the Global Forum on Nicotine to ensure that the scientific community can access factual information about our product.”

For more information on the data presented at GFN 2018, please view the abstract.

About JUUL Labs

JUUL Labs is a consumer product company dedicated to eliminating cigarettes by offering existing adult smokers a true alternative to combustible cigarettes. The company’s research shows more than one million smokers have already switched to JUUL, and we are working to enable millions more to switch in the coming years through technological innovations.

Media Contact: press@juul.com

JUUL Labs Presents Findings From Two Studies

SAN FRANCISCO (February 24, 2018) – JUUL Labs, Inc. today announced results from a preliminary study on the temperature regulation and harmful and potentially harmful constituents (HPHCs) of JUUL’s Virginia Tobacco 5% nicotine-e-liquid filled pod. The findings, “Characterization of Temperature Regulation and HPHC Profile of a Nicotine Salt-Based ENDS Product,” were presented at a poster session at The Society for Research on Nicotine & Tobacco’s 2018 Annual Meeting in Baltimore, Md.

Automated temperature regulation is designed to provide a consistent temperature across a range of operating conditions. In a laboratory setting, computational models of the temperature regulation performance, along with observation, were consistent with maintaining a temperature below 300 degrees Celsius under a range of operating conditions. This included a condition in which unfilled pods with a dry wick also maintained a temperature below 300 degrees Celsius.

The HPHC profile of aerosol generated from JUUL’s Virginia Tobacco 5% nicotine-e-liquid filled pod was characterized at an independent contract laboratory, Enthalpy Analytical. A panel of 31 analytes and HPHCs consistent with guidance provided by the U.S. Food and Drug Administration (FDA) was measured and compared with a U.S. commercial cigarette. Beyond three intended ingredients (nicotine, propylene glycol, glycerol) which were observed, 89% (25 of 28) of panel analytes were not detected (ND) or were below the level of quantification (BQL). Eleven percent (3 of 28) were observed at quantifiable levels, including NNN (at >99% reduction vs. the combusted cigarette); chromium (at 2% above level of quantification (LOQ)), significantly below Occupational Safety and Health Administration (OSHA) permissible exposure limits; and anabasine (at 25% above LOQ), a naturally occurring nicotine degradation product.

In addition, JUUL Labs presented data from a second poster, “Acute Use of Nicotine Salt-Based ENDS and Combusted Cigarettes,” demonstrating that no significant differences in Tmax, Cmax, AUC, baseline adjusted Cmax and baseline adjusted AUC were observed between JUUL and combusted cigarettes. This was true for both ad-lib and fixed sessions. Likewise, no significant differences were observed in measures of satisfaction (p>0.05) between JUUL and combusted cigarettes. The study was a single-center, randomized, crossover design conducted by New Zealand-based Christchurch Clinical Studies Trust that included 24 adult smokers. Study participants were assigned a different product every 120 minutes, which was randomized to be either a JUUL or combusted cigarettes.

Lead authors for the studies were Dr. I. Gene Gillman of Enthalpy Analytical and Dr. Christopher Wynn of Christchurch Clinical Studies Trust.

Consistent with the FDA regulations, JUUL cannot and does not make any claims that its products are less harmful or safer than cigarettes.

 

About JUUL Labs

JUUL Labs is a consumer product company dedicated to eliminating cigarettes by offering existing adult smokers a true alternative to combustible cigarettes that enables them to permanently switch. The company’s research shows that hundreds of thousands of smokers have already switched to JUUL, and we are working to enable millions more to switch in the coming years through technological innovations.

Media Contact: press@juul.com